Kinase Inhibitors Market Capacity and Share by Manufacturers 2022
In
pharmaceutical sector, anti – cancer drugs form the most lucrative segment.
From the past market trend it has shown that this anti – cancer drugs or kinase
inhibitors has accounted over 10% of the global market. In the forecasted year
of 2015 to 2022, Kinase Inhibitors Market CAGR is expected to witness a double
digit growth.The factors identified which are driving the growth of the Kinase
Inhibitors market are incidental rise of different types of cancer patients,
rise in the aging population and increase in the focus to launch innovative
medicines by the pharmaceutical companies. These key factors combined with
competition from several pharmaceutical and oncology associations to paunch new
product is propelling the growth of the market exponentially. Kinase inhibitors
are basically a type of enzyme of protein base. Use of Kinase enzyme helps to
shuffle the protein structure by the transfer of phosphates. These phosphates
get collected from ATP. ATP is Adenosine Triphosphate. Kinase on protein bases
has several functions. These functions includes regulating variety of cell
cycles and their phases, cell differentiation, cell proliferation, and
apoptosis. These functions helps to regulate various activities of cancerous
cell.
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Kinase
inhibitors are now considered to be the novel therapeutics. This is because
these inhibitors are targeted to improve the patients survival rate by several
preventive measures which will hinder the growth of tumors selectively as
opposed to the classical chemo therapy which indiscriminate the cell death.
Reports from American cancer association say that in the year 2014, the global
sales for small molecule kinase inhibitors generated USD 18.49 billion of
revenues for manufactures. This trend is expected to see a phenomenal growth
till the forecast period of 2022. The sales growth is expected to exceed the
wider cancer treating drug market in the upcoming years. This is because of
huge expansion of kinase inhibitors in terms of clinical usage among stratified
patient as an end user. Growth of this market is expected to improve by launch
and uptake of the advanced version of breakthrough therapies such as a marketed
product, imbruvica (Ibrutinib), candidate drugs pablociclib, Idelalisib and ABT
– 199.Market trend also quotes that there will more incidental rise of
cancerous patients in the upcoming years. These is validated mostly the global
associations related to oncology treatment. So the manufactures for kinase
inhibitors have a potential opportunity in the near future. This is mainly
because the kinase inhibitors are are being considered as a key medication to
prevent proliferation of cancerous cells. Most of the drugs which are going to
be used to oncology treatment in clinical trials phase are expected to be
launched in the next five to six years based on the strength of kinase
activities of these drugs. However it has also been identified that healthcare
cost containment issues and cost cutting in research funding are the major
restraints for the growth of this market. For example, the cost of Tyrosin
Kinase Inhibitors (TKI) was approximated to be USD 26400 in non pharmaceutical
spending in the year 2012 as per American Cancer Society.
The
global market for Kinase Inhibitors are segmented on the basis of types, by
geography and by target end users. The target end users for this market are
mainly pharmaceutical companies, private and government research institutes,
healthcare institutes and academic institutes. By types the global market is
further segmented into Tyrosine Kinase Inhibitors (TKI), Receptor Tyrosine
Kinase Inhibitors which includes EGFR, PDGFR, VEGFR,HER2 which is a type of Non
Receptor Tyrosine Kinase Inhibitor (RCTKI), BCR – ABL, Janus Kinase Inhibitor
(JAK), Mesenchymal Epithelial Transition Growth Factor (c – MET), Speen
Tyrosine Kinase (SYK) Inhibitors which is again further divided into classes
such as Mulikinase Inhibitors, Threonine Kinase Inhibitors, m TOR Kinase
Inhibitors, B RAFM, RHO Kinase Inhibitors, Cyclin Dependent Kinase Inhibitors,
Aurora Kinase Inhibitors, MAP or MEK Kinase Inhibitors, JNK Inhibitors, Protein
Kinase c Inhibitors, PI3K Inhibitors, others ( Monoclonal Antibody Kinase
Inhibitors) which is again classified into Humanized Monoclonal Antibody,
Chimeric Monoclonal Antibody, Humanized Monoclonal Antibody.
By
geography the global market is segmented into major regions which include North
America, Europe, Asia Pacific and rest of the world (R o W). As with other
medicines for cancer the dominant countries for the growth of Kinase Inhibitor
market are Japan, the European Union countries and the United States. These
countries generate the highest revenue the Kinase Inhibitor market. However
over the next five to six years this market is expected to see an exponential growth
from BRIC countries. This is because of increase in the number of health
insurances, healthcare reforms, and increase in the affluence segment from this
region. In the forecasted period of 2015 to 2022 the first generation of Kinase
Inhibitor drug is also expected to lose intellectual property which includes
patents and trademarks protection and competition from low cost generic
substitutes. This will temporarily restricted the expected expansion in many
lucrative submarkets.The key players in Kinase inhibitors market are Bristol
Meyers Squibb, Boehringer Ingelhgeim, Cytrx Corporation, Eisai Inc., Eton
Bioscience Inc., Novartis International Ag, Glaxosmithkline, Merk Serona Sa,
Osi Pharmaceuticals Llc., Pfizer. These major leaders face a stiff competition
to retain their sustainable foothold in this market measured on different
competitive market dynamics. For example Novartis’s Gleevec for leukemia
treatment is amongst the best selling Kinase Inhibitors.
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